ANA-12

产品编号: DC8029 Featured
ANA-12
结构式
219766-25-3
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中国地区超过5000个高品质化合物库存
应用领域
ANA-12是有效,选择性的 TrkB 拮抗剂,对高亲和力和低亲和力位点的IC50 分别为45.6 nM和41.1 μM。
Cas No.: 219766-25-3
名称: N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide
别名: ANA 12,ANA12
SMILES: C12=CC=CC=C1C=C(C(NC1=CC=CC=C1C(=O)NC1CCCCNC1=O)=O)S2
分子式: C22H21N3O3S
分子量: 407.49
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.ANA-12 prevented activation of the receptor by BDNF with a high potency. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Saturation binding studies with TrkBECD-Fc showed that ANA-12 binds TrkBECD-Fc with a Kd of 12 μM . The selective TrkB (tropomyosin-receptor-kinase) antagonist ANA-12 reduced OIH when given one or seven days after cessation of morphine For the detailed information of ANA-12, the solubility of ANA-12 in water, the solubility of ANA-12 in DMSO, the solubility of ANA-12 in PBS buffer, the animal experiment (test) of ANA-12, the cell expriment (test) of ANA-12, the in vivo, in vitro and clinical trial test of ANA-12, the EC50, IC50,and affinity,of ANA-12, Please contact DC Chemicals.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC8029 ANA-12 ANA-12是有效,选择性的 TrkB 拮抗剂,对高亲和力和低亲和力位点的IC50 分别为45.6 nM和41.1 μM。
DC7145 GW441756 GW 441756是特异的高活性原肌球蛋白相关激酶A(TrkA)抑制剂,IC50为2 nM,对c-Raf1和CDK2几乎无活性。