AWZ1066S

产品编号: DC20243 Featured
AWZ1066S
结构式
239272-16-1
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中国地区超过5000个高品质化合物库存
应用领域
AWZ1066S 是一种高度特异性的抗 Wolbachia 的候选药物,可于用丝虫病的短期治疗,其在细胞中测得的 EC50 值为 2.5 nM。
Cas No.: 239272-16-1
名称: N-cyclopropyl-3-fluoro-4-methyl-5-(3-((1-(2-(2-(methylamino)ethoxy)phenyl)cyclopropyl)amino)-2-oxopyrazin-1(2H)-yl)benzamide
别名: AWZ1066S,AWZ-1066S,AWZ 1066S
SMILES: C1=CC=NC2N=C(N3[C@H](C)COCC3)N=C(NCC3=CC=CN=C3C(F)(F)F)C1=2
分子式: C19H19F3N6O
分子量: 404.16
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: AWZ1066S is a highly specific anti-Wolbachia candidate selected through a lead optimization program focused on balancing efficacy, safety and drug metabolism/pharmacokinetic (DMPK) features of a thienopyrimidine/quinazoline scaffold derived from phenotypic screening. AWZ1066S shows superior efficacy to existing anti-Wolbachia therapies in validated preclinical models of infection and has DMPK characteristics that are compatible with a short therapeutic regimen of 7 days or less. AWZ1066S is well-positioned for onward development and has the potential to make a significant impact on communities affected by filariasis.
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LOT NO. DOWNLOAD
2018-0101
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