ATH686

产品编号: DC10921 Featured
ATH686
结构式
853299-52-2
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中国地区超过5000个高品质化合物库存
应用领域
ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase.
Cas No.: 853299-52-2
名称: 1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea
别名: ATH 686;ATH-686
SMILES: N(C1=CC=C(OC2C=CN=C(N)N=2)C=C1)C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)=O
分子式: C25H28F3N7O2
分子量: 515.541
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase; selectively kills leukemic cells harboring mutant FLT3 with no apparent effect on cells harboring wild-type FLT3, via inhibition of FLT3 kinase activity; potently inhibits cell proliferation of FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells (IC50<1 nM), via induction of apoptosis.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC10921 ATH686 ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase.