GAK inhibitor 12r

产品编号: DC11052 Featured
GAK inhibitor 12r
结构式
2241325-66-4
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中国地区超过5000个高品质化合物库存
应用领域
GAK抑制剂12r是一种高效,选择性的细胞周期蛋白G相关激酶(GAK)抑制剂,Kd为89 nM;在468种激酶的不同组中仅靶向8种其他激酶,抑制率超过90%;表现出广谱抗病毒活性对于DENV-2,EC50为0.82uM,也显示出对抗登革热病毒的活性,包括人原代树突状细胞,以及对抗无关埃博拉病毒和基孔肯雅病毒的功效。
Cas No.: 2241325-66-4
名称: 4-(3-(cis-2,6-Dimethylmorpholino)isothiazolo[4,3-b]pyridin-6-yl)-2-methoxyaniline
别名:
SMILES: NC1=CC=C(C2C=NC3=C(N4C[C@@H](C)O[C@@H](C)C4)SN=C3C=2)C=C1OC
分子式: C19H22N4O2S
分子量: 370.471
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM; targets only 8 other kinases with greater than 90% inhibition in a diverse panel of 468 kinases; demonstrates broad-spectrum antiviral activity with EC50 of 0.82 uM against DENV-2, also shows activity against dengue virus, including in human primary dendritic cells, and efficacy against the unrelated Ebola and chikungunya viruses.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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