UE2343(Xanamem)

产品编号: DC11783 Featured
UE2343(Xanamem)
结构式
1346013-80-6
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中国地区超过5000个高品质化合物库存
应用领域
UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2.
Cas No.: 1346013-80-6
名称: (5-(1H-pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone
别名: UE-2343;UE 2343;Xanamem
SMILES: C(C1C=C(C2=CNN=C2)SC=1)(N1[C@@]([H])2CC[C@@]1([H])C[C@](O)(C1=NC=CC=N1)C2)=O
分子式: C19H19N5O2S
分子量: 381.454
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2; displays a superior preclinical profile for further development, and shows potential for cognitive impairment in early Alzheimer's disease (AD).
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC11783 UE2343(Xanamem) UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2.