JAK3-IN-2

产品编号: DC21158 Featured
JAK3-IN-2
结构式
1443235-95-7
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中国地区超过5000个高品质化合物库存
应用领域
A potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM.
Cas No.: 1443235-95-7
名称: ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
别名: JAK3 inhibitor 2
SMILES:
分子式: C19H18N4O3
分子量: 350.378
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM; dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK; blocks cytokine signaling through JAK3, but not through other JAK family enzymes; inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM; sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis.
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COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC8258 Baricitinib phosphate Baricitinib phosphate(INCB 028050; LY 3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2,showed potent activity against COVID-19(SARS-COV-2).
DC21158 JAK3-IN-2 A potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM.