DLin-KC2-DMA

产品编号: DC12381
DLin-KC2-DMA
结构式
1190197-97-7
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中国地区超过5000个高品质化合物库存
应用领域
DLin-KC2-DMA 是一种可用于siRNA 传递的阳离子/可电离的脂质。
Cas No.: 1190197-97-7
名称: 2,2-dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane
别名:
SMILES: CN(CCC1OC(CCCCCCCC/C=C\C/C=C\CCCCC)(CCCCCCCC/C=C\C/C=C\CCCCC)OC1)C
分子式: C43H79NO2
分子量: 641.61
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: DLin-KC2-DMA is useful cationic lipid for siRNA delivery. DLin-KC2-DMA (2,2-dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane), and DLin-MC3-DMA, which are 100-fold and 1000-fold more potent, respectively, in silencing of a hepatic gene (Factor VII) in comparison to the previous generation lipid DLin-DMA (1,2-dilinoleyloxy-N,N-dimethyl-3-aminopropane).The ED50 (median effective dose) for LNP containing DLin-MC3-DMA to silence Factor VII in mice and TTR in non-human primates was 0.005 mg/kg and 0.03 mg/kg, respectively.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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DC12381 DLin-KC2-DMA DLin-KC2-DMA 是一种可用于siRNA 传递的阳离子/可电离的脂质。
DC10800 DLin-MC3-DMA D-Lin-MC3-DMA 是一种可离子化的氨基脂质类化合物, 是一种有效的递送 siRNA 载体。目前广泛应用于肿瘤基因治疗研究中。