EIDD-2801

产品编号: DC27035 Featured
EIDD-2801
结构式
2349386-89-4
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中国地区超过5000个高品质化合物库存
应用领域
EIDD-2801 is an isopropylester prodrug of the ribonucleoside analog N4-hydroxycytidine (NHC, EIDD-1931) that has shown broad anti-influenza virus activity in cultured cells and mice.
Cas No.: 2349386-89-4
名称: Uridine, 4-oxime, 5'-(2-methylpropanoate)
别名: EIDD2801,EIDD 2801
SMILES:
分子式: C13H19N3O7
分子量: 329.31
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Mechanism of action: EIDD-2801 is hydrolyzed in vivo to N4-hydroxycytidine, which is phosphorylated in tissue to the active 5’-triphosphate form, and incorporated into the genome of new virions, resulting in the accumulation of inactivating mutations, known as viral error catastrophe.A remdesivir resistant mutant mouse hepatitis virus has also been shown to have increased sensitivity to N4-hydroxycytidine.

Indication: EIDD-1931 and its prodrug EIDD-2801 is being studied for its activity against a number of viral infections including influenza, MERS-CoV, and SARS-CoV-2.

Absorption: EIDD-2801 is orally bioavailable in non-human primates.

Metabolism:EIDD-2801 is hydrolyzed to N4-hydroxycytidine, which distributes into tissues.<2> Once inside cells, N4-hydroxycytidine is phosphorylated to the 5'-triphosphate form.

 
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MSDS
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DC27035 EIDD-2801 EIDD-2801 is an isopropylester prodrug of the ribonucleoside analog N4-hydroxycytidine (NHC, EIDD-1931) that has shown broad anti-influenza virus activity in cultured cells and mice.
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