Maytansine

产品编号: DC28020 Featured
Maytansine
结构式
35846-53-8
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中国地区超过5000个高品质化合物库存
应用领域
Maytansine, a benzoansamacrolide, is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations.
Cas No.: 35846-53-8
名称: Maytansine
别名:
SMILES: COC1C(Cl)=C2N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(C)=O)[C@@]3(C)[C@H]([C@H](C)[C@@H]4C[C@](NC(=O)O4)(O)[C@H](OC)C=C/C=C(/C)CC(C=1)=C2)O3
分子式: C34H46N3O10Cl
分子量: 692.19
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Maytansine, a benzoansamacrolide, is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. However, it failed as an anticancer agent in human clinical trials because of lack of tumor specificity and unacceptable systemic toxicity. The potent cell killing ability of maytansine can be used in a targeted delivery approach, such as an antibody-drug conjugate, for the selective delivery of the drug and destruction of cancer cells. 

The ansamycin antibiotic was originally isolated from the Ethiopian shrub Maytenus serrata and binds to tubulin at the rhizoxin binding site. It inhibits microtubule assembly, induces microtubule disassembly, and disrupts mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. 

Maytansine and its analogs (maytansinoids DM1 and DM4) are potent microtubule-targeted compounds that inhibit proliferation of cells at mitosis. The antibody-maytansinoid conjugates consist of maytansinoids attached to tumor-specific antibodies.
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MSDS
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MSDS_3090_DC28020_35846-53-8
COA
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产品编号 产品名称 应用领域
DC28020 Maytansine Maytansine, a benzoansamacrolide, is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations.
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