Monomethyl auristatin E (vedotin)

产品编号: DC7021 Featured
Monomethyl auristatin E (vedotin)
结构式
474645-27-7
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中国地区超过5000个高品质化合物库存
应用领域
Monomethyl auristatin E (MMAE; SGD-1010) 是海兔毒素10的合成衍生物,通过抑制微管蛋白聚合而起到有效的有丝分裂抑制作用。 MMAE广泛用作细胞毒性成分制作抗体-药物偶联物 (ADCs) 以治疗癌症。
Cas No.: 474645-27-7
名称: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxohe;[3H]-Vedotin;MMAE;MMAE(Monomethyl Auristain E);MONOMETHYL AURISTATIN E;Vedotin;N-Methyl-L-valyl
别名: MMAE, SGD-1010
SMILES: CN[C@H](C(N[C@H](C(N(C([C@@H](CC(N1CCC[C@H]1[C@@H]([C@H](C(N[C@@H]([C@H](C1C=CC=CC=1)O)C)=O)C)OC)=O)OC)[C@H](CC)C)C)=O)C(C)C)=O)C(C)C
分子式: C39H67N5O7
分子量: 717.97859120369
纯度: >99%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Monomethyl auristatin E (MMAE, vedotin) is a very potent anti-mitotic agent that inhibits cell division by
blocking the polymerisation of tubulin. Because of its super toxicity, it cannot be used as a drug itself. In
recent cancer therapy developments, it is linked to a monoclonal antibody (mAb) that recognizes a
specific marker expression in cancer cells and directs MMAE to the cancer cells. The linker linking MMAE
to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the
antibody-drug-conjugate/ADC has bound to the specific cancer cell antigen and entered the cancer cell,
thus releasing the toxic MMAE and activating the potent anti-mitotic mechanism.For the detailed information of Monomethyl auristatin E (MMAE, vedotin), the solubility of Monomethyl auristatin E (MMAE, vedotin) in water, the solubility of Monomethyl auristatin E (MMAE, vedotin) in DMSO, the solubility of Monomethyl auristatin E (MMAE, vedotin) in PBS buffer, the animal experiment (test) of  Monomethyl auristatin E (MMAE, vedotin), the cell expriment (test) of Monomethyl auristatin E (MMAE, vedotin), the in vivo, in vitro and clinical trial test of Monomethyl auristatin E (MMAE, vedotin), the EC50, IC50,and Affinity of Monomethyl auristatin E (MMAE, vedotin), Please contact DC Chemicals.
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References:
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
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DC7021 Monomethyl auristatin E (vedotin) Monomethyl auristatin E (MMAE; SGD-1010) 是海兔毒素10的合成衍生物,通过抑制微管蛋白聚合而起到有效的有丝分裂抑制作用。 MMAE广泛用作细胞毒性成分制作抗体-药物偶联物 (ADCs) 以治疗癌症。