| DC31023 |
PT2977
|
PT2977 (MK-6482) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC)[1]. |
| DC20000 |
LR-90
|
LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model. |
| DC11219 |
Hoechst 33342
|
bisBenzimide H 33342; HOE 33342small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM). |
| DC27035 |
EIDD-2801
|
EIDD-2801 is an isopropylester prodrug of the ribonucleoside analog N4-hydroxycytidine (NHC, EIDD-1931) that has shown broad anti-influenza virus activity in cultured cells and mice. |
| DC26231 |
Furin Inhibitor II
|
Hexa-D-arginine (Furin Inhibitor II) 是一种稳定的 furin 抑制剂，对 furin，PACE4 和 PC1 的 Ki 值分别为 106 nM，580 nM 和 13.2 μM。Hexa-D-arginine 在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。 |
| DC27050 |
GSK2983559
|
GSK2983559 free acid (compound 3) 是一种高效、特异性的，口服有效的受体相互作用蛋白 2 (RIP2) 激酶抑制剂。GSK2983559 free acid 在体内和人类炎症性肠病外植体样本中，具有良好的阻断多种促炎细胞因子反应活性。 |
| DC21672 |
SNAP-94847 hydrochloride
|
SNAP 94847 是一种新型的，高亲和力的选择性黑色素浓缩激素受体 1 (MCHR1) 拮抗剂，其 (Ki= 2.2 nM, Kd=530 pM)，它对 MCHα1A 和 MCHD2 受体分别显示出 >80 倍和 >500 倍的选择性。 SNAP 94847 以高亲和力与小鼠和大鼠 MCHR1 结合，与其他 GPCR，离子通道，酶和转运蛋白的交叉反应性很小。 |
| DCAPI1051 |
Arbidol HCl (Umifenovir)
|
Umifenovir is currently being investigated as a potential treatment and prophylactic agent for COVID-19 caused by SARS-CoV2 infections in combination with both currently available and investigational HIV therapies. Arbidol hydrochloride (Umifenovir hydrochloride) is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane IC50 value: Target: Antiviral; Anti-influenza agent in vitro: Arbidol was found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with 50% inhibitory concentration (IC50) ranging from 2.7 to 13.8 microg/ml. |
| DC8759 |
Thiamet G
|
Thiamet G is a potent and selective inhibitor of O-GlcNAcase that demonstrates a Ki value of 21 nM. |
| DCAPI1390 |
Atovaquone (Atavaquone)
|
Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia. |
