PF-4708671

产品编号: DC7229 Featured
PF-4708671
结构式
1255517-76-0
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中国地区超过5000个高品质化合物库存
应用领域
PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM.
Cas No.: 1255517-76-0
名称: 1H-Benzimidazole,2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-
别名: PF 4708671; PF4708671
SMILES: FC(C1=CC=C2N=C(CN3CCN(C4=NC=NC=C4CC)CC3)NC2=C1)(F)F
分子式: C19H21F3N6
分子量: 390.410
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 iso Form or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1.For the detailed information of PF-4708671, the solubility of PF-4708671 in water, the solubility of PF-4708671 in DMSO, the solubility of PF-4708671 in PBS buffer, the animal experiment (test) of PF-4708671, the cell expriment (test) of PF-4708671, the in vivo, in vitro and clinical trial test of PF-4708671, the EC50, IC50,and Affinity of PF-4708671, Please contact DC Chemicals.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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