PTC596

产品编号: DC28030 Featured
PTC596
结构式
1610964-64-1
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中国地区超过5000个高品质化合物库存
应用领域
PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.
Cas No.: 1610964-64-1
名称: 5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine
别名: PTC596 ,PTC-596 ,PTC 596
SMILES: NC1N=C(N2C(C)=NC3C2=CC(=CC=3)F)N=C(NC2C=CC(C(F)(F)F)=CC=2)C=1F
分子式: C19H13F5N6
分子量: 420.330
纯度: >98%
保存条件: C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
Description:
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MSDS
TITLE DOWNLOAD
MSDS_3271_DC28030_1610964-64-1
COA
LOT NO. DOWNLOAD
产品编号 产品名称 应用领域
DC10041 KR-33493 KR-33493 是一个有效的 Fas 介导细胞死亡 (FAF1) 的抑制剂。
DC28030 PTC596 PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.