PX 12

产品编号: DC7992 Featured
PX 12
结构式
141400-58-0
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中国地区超过5000个高品质化合物库存
应用领域
PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1(Trx-1) currently in clinical development as an antitumor agent; IC50=7 uM in Hela, MTT assay, 72 h.
Cas No.: 141400-58-0
名称: 2-[(1-Methylpropyl)dithio]-1H-imidazole; IV-2
别名: PX-12,PX12
SMILES: CCC(SSC1=NC=CN1)C
分子式: C7H12N2S2
分子量: 188.310
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1(Trx-1) currently in clinical development as an antitumor agent; IC50=7 uM in Hela, MTT assay, 72 h.Based on MTT assays, PX-12 inhibited the growth of HeLa cells with an IC50 value of ~7 μM at 72 h. DNA flow cytometry analysis indicated that 5 and 10 μM PX-12 significantly induced a G2/M phase arrest of the cell cycle. PX-12 also increased the number of dead cells and annexin V-fluorescein isothiocyanate-positive cells For the detailed information of PX 12, the solubility of PX 12 in water, the solubility of PX 12 in DMSO, the solubility of PX 12 in PBS buffer, the animal experiment (test) of PX 12, the cell expriment (test) of PX 12, the in vivo, in vitro and clinical trial test of PX 12, the EC50, IC50,and affinity,of PX 12, Please contact DC Chemicals.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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