SB-431542

产品编号: DC5189 Featured
SB-431542
结构式
301836-41-9
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中国地区超过5000个高品质化合物库存
应用领域
SB-431542 是一种有效,选择性的 ALK5/TGF-β type I Receptor 抑制剂,IC50 值为 94 nM。
Cas No.: 301836-41-9
名称: 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide
别名: SB431542, SB 431542
SMILES: C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
分子式: C22H16N4O3
分子量: 384.39
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SB-431542 is a novel small molecule inhibitor of the type I TGF-beta receptor, on a panel of human malignant glioma cell lines. SB-431542 blocked the phosphorylation and nuclear translocation of the SMADs, intracellular mediators of TGF-beta signaling, with decreased TGF-beta-mediated transcription. Furthermore, SB-431542 inhibited the expression of two critical effectors of TGF-beta-vascular endothelial growth factor and plasminogen activator inhibitor-1. SB-431542 treatment of glioma cultures inhibited proliferation, TGF-beta-mediated morphologic changes, and cellular motility. Together, our results suggest that small molecule inhibitors of TGF-beta receptors may offer a novel therapy For malignant gliomas by reducing cell proliferation, angiogenesis, and motility.For the detailed information of SB-431542, the solubility of SB-431542 in water, the solubility of SB-431542 in DMSO, the solubility of SB-431542 in PBS buffer, the animal experiment (test) of SB-431542, the cell expriment (test) of SB-431542, the in vivo, in vitro and clinical trial test of SB-431542, the EC50, IC50,and Affinity of SB-431542, Please contact DC Chemicals.
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MSDS
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MSDS_1466_DC5189_301836-41-9
COA
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产品编号 产品名称 应用领域
DC6306 LY2157299(Galunisertib) Galunisertib (LY2157299) 是一种选择性的 TGF-β 受体 I 型 (TGF-βRI) 激酶抑制剂,IC50 为 56 nM。
DC5189 SB-431542 SB-431542 是一种有效,选择性的 ALK5/TGF-β type I Receptor 抑制剂,IC50 值为 94 nM。