Thiamet G

产品编号: DC8759 Featured
Thiamet G
结构式
1009816-48-1
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中国地区超过5000个高品质化合物库存
应用领域
Thiamet G is a potent and selective inhibitor of O-GlcNAcase that demonstrates a Ki value of 21 nM.
Cas No.: 1009816-48-1
名称:
别名: Thiamet-G
SMILES: CCN(C1=CC=C(C2=C(Cl)C(=O)C3=NC=CC=C3C2=O)C=C1)CC
分子式: C9H16N2O4S
分子量: 248.300
纯度: >98%
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Thiamet G is a potent and selective inhibitor of O-GlcNAcase that demonstrates a Ki value of 21 nM.Thiamet G increases cellular O-GlcNAc-modified protein levels (EC50 = 30 nM) and blocks phosphorylation of tau protein both in cultured PC-12 cells and in rats (200 mg/kg/day). Thiamet G is the first highly potent O-GlcNAcase inhibitor known to be orally bioavailable and effectively cross the blood brain barrier.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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