2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
CAS NO.：1166393-85-6 Product Name： Synonyms：PF4618433 EINEC: Molecular Formula：C24H27N7O2 Molecular Weight：445.5
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.
