2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
A dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a member of the PI3K-related kinase subfamily of protein kinases, is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway; mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/Akt/mTOR signaling pathway. For the detailed information of CC-115, the solubility of CC-115 in water, the solubility of CC-115 in DMSO, the solubility of CC-115 in PBS buffer, the animal experiment (test) of CC-115, the cell expriment (test) of CC-115, the in vivo, in vitro and clinical trial test of CC-115, the EC50, IC50,and affinity,of CC-115, For the detailed information of CC-115, the solubility of CC-115 in water, the solubility of CC-115 in DMSO, the solubility of CC-115 in PBS buffer, the animal experiment (test) of CC-115, the cell expriment (test) of CC-115, the in vivo, in vitro and clinical trial test of CC-115, the EC50, IC50,and affinity,of CC-115, Please contact DC Chemicals.
