2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
CLR1501 is a synthetic analogs of the tumor-targeting agent alkylphosphocholine (APC), which is specifically attracted to cancer cells. CLR1501 is molecularly altered to carry fluorescent dyes that glow under lights with specific wavelength in the green (CLR1501) . Viewed under appropriate conditions, CLR1501 dye makes tumor cells "light up" so that it can be readily distinguished from neighboring normal brain tissue.The results confirmed that CLR150 was attracted to tumor cells, and emitted light of specific wavelengths under appropriate imaging conditions. Both APC analogs provided "excellent fluorescence discrimination of tumor from adjacent normal brain." Tumors could be clearly seen using different types of commercially available imaging systems.
Imaging with CLR1501 green dye showed fluorescence similar to that achieved with currently used 5-ALA dye. The use of near-infrared fluorescence would offer additional advantages during actual surgery, compared to fluorescence in the visible-light range.
