2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
PLX5622 is a a potent, selective, orally active inhibitor of CSF1R tyrosine kinase (c-Fms) activity with Ki of 5.9 nM, 60-fold less potency against KIT; dispalys least 50-fold selectivity over 4 related kinases, and over 100-fold selectivity against a panel of 230 kinases; prevents microglial plaque association and improves cognition in 3xTg-AD mice, also depletes microglia and alleviates the catatonic symptoms of Cnp mutants.Rheumatoid ArthritisPhase 1 Discontinued
