2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
A novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively; displays approximately 10-fold lower potency for Kv3.3 channels, and does not interact with a wide range of ion channels, receptors, and transporters; increases hKv3.1b and hKv3.2a currents by 1049 ± 198% and 226 ± 39%, respectively, at 30 uM; rescue the fast firing capability of FS interneurons following a reduction in Kv3 channel availability, has the potential to rescue normal function and therapeutic benefit in disorders like schizophrenia or age-related cognitive decline.
