2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Etelcalcetide, also known as AMG 416 and KAI-4169, is a D-amino peptide calcimimetic undergoing clinical evaluation for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is administered intravenously at the end of each dialysis session. It functions by binding to and activating the calcium-sensing receptor (CaSR) in the parathyroid gland as an allosteric activator, resulting in PTH reduction and suppression. Elevated PTH is often observe in patients with CKD. On August 25, 2015 Amgen Inc. announced its submission of a New Drug Application to the Food and Drug Administration for etelcalcetide. For the detailed information of Etelcalcetide Hydrochloride(AMG 416), the solubility of Etelcalcetide Hydrochloride(AMG 416) in water, the solubility of Etelcalcetide Hydrochloride(AMG 416) in DMSO, the solubility of Etelcalcetide Hydrochloride(AMG 416) in PBS buffer, the animal experiment (test) of Etelcalcetide Hydrochloride(AMG 416), the cell expriment (test) of Etelcalcetide Hydrochloride(AMG 416), the in vivo, in vitro and clinical trial test of Etelcalcetide Hydrochloride(AMG 416), the EC50, IC50,and affinity,of Etelcalcetide Hydrochloride(AMG 416), For the detailed information of Etelcalcetide Hydrochloride(AMG 416), the solubility of Etelcalcetide Hydrochloride(AMG 416) in water, the solubility of Etelcalcetide Hydrochloride(AMG 416) in DMSO, the solubility of Etelcalcetide Hydrochloride(AMG 416) in PBS buffer, the animal experiment (test) of Etelcalcetide Hydrochloride(AMG 416), the cell expriment (test) of Etelcalcetide Hydrochloride(AMG 416), the in vivo, in vitro and clinical trial test of Etelcalcetide Hydrochloride(AMG 416), the EC50, IC50,and affinity,of Etelcalcetide Hydrochloride(AMG 416), Please contact DC Chemicals.
