Avacopan 产品说明书 Chemicals
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产品编号 DC11688
名称 Avacopan

化学性质

CAS 1346623-17-3
分子式 C33H35F4N3O2
分子量 581.656
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description CAS NO.：1346623-17-3
Product Name：(2R,3S)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide
Synonyms：Avacopan; CCX168; CCX-168; CCX 168
EINEC:
Molecular Formula：C33H35F4N
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


A potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM; shows no activity (IC50 >5,000 nM)for C5aR-related receptors C5L2, C3aR, ChemR23, GPR1 and FPR1; inhibits C5a-mediated chemotaxis of U937 cells with pA2 of 0.2 nM; shows activity in mouse model of ANCA-induced glomerulonephritis.
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