2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
UNC569 is a potent, reversible and ATP-competitive inhibitor of Mer receptor tyrosine kinase (RTK) (IC50: 2.9 nM). UNC 569 inhibits Mer activation and downstream signaling through ERK1/2 and AKT and was capable of inducing >50% reduction in tumor burden compared to references. Potential therapeutic for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors (ATRT).
