2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Naloxegol (NKTR-118) which is a novel PEGylated form of naloxol, a naloxone analog. Naloxegol has shown strong selectivity (more than 6000 folds) toward peripheral mu receptors and has been approved as first oral PAMORA for OIC due to use of opioids for non-cancer pain. PEGylation greatly restricts the activity of naloxegol to periphery. Naloxegol has been developed by Nektar Therapeutics and is marketed by AstraZeneca under the brand name MOVANTIK and received US-FDA approval on 16 Aug 2014.
