2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
ME0328 is a potent, selective inhibitor of ADP-ribosyltransferase ARTD3/PARP3 with IC50 of 0.89 uM; displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50=6.3, 10.8 and >30 uM respectively); potentiates vinorelbine sensitization in breast cancer cell lines at the G2/M boundary, also potentiates vinorelbine-induced PARP3 inhibition, mitotic arrest, and apoptosis.
