Alofanib 产品说明书 Chemicals
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产品编号 DC11931
名称 Alofanib

化学性质

CAS 1612888-66-0
分子式
分子量
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


Alofanib ((RPT-835, ES 000835) is a potent, selective, allosteric FGFR2 inhibitor that significantly inhibits bFGF-induced proliferation of HUVEC cells with IC50 of 11 nM; suppresses proliferation of SVEC-4-10 cells with IC50 of 58 nM, inhibits growth of FGFR2-expressing SKOV3 cells with GI50 of 0.37 uM; inhibits experimental FGF-induced angiogenesis in vivo.
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