2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
In an in vitro biochemical assay, EPZ015866(GSK591) potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z-138 cells, EPZ015866(GSK591) inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, EPZ015866(GSK591) is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases.
