2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
LY3177833 is a novel CDC7 inhibitor,CDC7/DBF4 IC50 = 3.3 nM, pMCM2 (S53) IC50 = 290 nM and IVTI TEC70 = 1.6 mcM. LY-3177833 showed MED = 5 mg/kg (p.o.) in vivo. LY-3177833 strongly impacted chromosome dynamics. In mouse xenograft models, broad antitumor activity was associated with robust dose/exposure-dependent in vivo target inhibition. In addition, the preclinical profile of LY-3177833 was different from nonselective CDC7 inhibitors and cytotoxic agents, something that supports its clinical development with a continuos dosing regime
