BQU57 产品说明书 Chemicals
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产品编号 DC8202
名称 BQU57

化学性质

CAS 1637739-82-2
分子式 C16H13F3N4O
分子量 334.3
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


BQU57 is a potent and selective GTPase Ral Inhibitor. It showed selectivity for Ral relative to the GTPases Ras and RhoA and inhibited tumour xenograft growth to a similar extent to the depletion of Ral using RNA interference. It inhibited the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. The binding of the BQU57 to RalB was confirmed by isothermal titration calorimetry, surface plasmon resonance and 1H-15N transverse relaxation-optimized spectroscopy (TROSY) NMR spectroscopy. The Ras-like GTPases RalA and RalB are important drivers of tumour growth and metastasis. BQU57 that blocks Ral function would be valuable as research tools and for cancer therapeutics. For the detailed information of GSK-503, the solubility of GSK-503 in water, the solubility of GSK-503 in DMSO, the solubility of GSK-503 in PBS buffer, the animal experiment (test) of GSK-503, the cell expriment (test) of GSK-503, the in vivo, in vitro and clinical trial test of GSK-503, the EC50, IC50,and affinity,of GSK-503, For the detailed information of GSK-503, the solubility of GSK-503 in water, the solubility of GSK-503 in DMSO, the solubility of GSK-503 in PBS buffer, the animal experiment (test) of GSK-503, the cell expriment (test) of GSK-503, the in vivo, in vitro and clinical trial test of GSK-503, the EC50, IC50,and affinity,of GSK-503, Please contact DC Chemicals.
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