SA4503 2HCl 产品说明书 Chemicals
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产品编号 DC8227
名称 SA4503 2HCl

化学性质

CAS 165377-44-6
分子式 C23H34CL2N2O2
分子量 441.43
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


in vitro: SA4503 showed little affinity for 36 other receptors, ion channels and second messenger systems. SA4503 significantly increased the KD value, but did not affect the Bmax value for specific (+)-[3H]pentazocine binding. SA4503 is a potent and selective agonist for the sigma 1 receptor subtype in the brain. At concentrations of 1-10μM, SA4503 reduced SOD1(G93A)-induced cell death in a concentration-dependent manner. in vivo: The intravenous administration of SA4503 (0.01-1.28 mg/kg) did not significantly alter the firing rate or pattern of spontaneously active DA neurons in either the SNC or VTA. A single injection of either 0.1 or 0.3 mg/kg i.p. of SA4503 did not alter the number of spontaneously active SNC and VTA DA neurons. In contrast, a single injection of 1 mg/kg i.p. of SA4503 produced a significant decrease and increase in the number of spontaneously active SNC and VTA DA neurons, respectively. SA4503 suppressed the progression of ALS in an SOD1(G93A) ALS mouse model. SA4503 did not affect the onset time of ALS. However, it significantly extended the survival time in the SOD1(G93A) mice compared with a vehicle-treated group. For the detailed information of SA4503 2HCl, the solubility of SA4503 2HCl in water, the solubility of SA4503 2HCl in DMSO, the solubility of SA4503 2HCl in PBS buffer, the animal experiment (test) of SA4503 2HCl, the cell expriment (test) of SA4503 2HCl, the in vivo, in vitro and clinical trial test of SA4503 2HCl, the EC50, IC50,and affinity,of SA4503 2HCl, For the detailed information of SA4503 2HCl, the solubility of SA4503 2HCl in water, the solubility of SA4503 2HCl in DMSO, the solubility of SA4503 2HCl in PBS buffer, the animal experiment (test) of SA4503 2HCl, the cell expriment (test) of SA4503 2HCl, the in vivo, in vitro and clinical trial test of SA4503 2HCl, the EC50, IC50,and affinity,of SA4503 2HCl, Please contact DC Chemicals.
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