2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over FRAP (mTOR) (IC50 = 5.3 µM). Compound 401 exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Compound 401 has been shown to induce apoptosis and inhibit FRAP-dependent growth in TSC1-/- murine embryo fibroblasts.
For the detailed information about the solubility of Compound 401 in water, the solubility of Compound 401 in DMSO, the solubility of Compound 401 in PBS buffer, the animal experiment（test） of Compound 401,the in vivo,in vitro and clinical trial test of Compound 401,the cell experiment（test） of Compound 401,the IC50, EC50 and Affinity of Compound 401, please contact DC Chemicals.
