2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Centrinone is a selective and reversible inhibitor of polo-like kinase 4 (Plk4), a serine-threonine protein kinase that initiates centriole/centrosome assembly.
Centrinone has been used to reversibly remove centrosomes from human and other vertebrate cells. Treatment with Centrinone at sub-micromolar concentrations allows persistent and reversible depletion of centrioles from cultured human and mouse cells, leading to loss of centrosomes and primary cilia.
