2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
BI-9564 (MW 353.4) is a BRD9 / 7 specific inhibitor that has been developed in collaboration with Boehringer Ingelheim. This probe was discovered through fragment-based screening and optimized by structure guided design. BI-9564 binds to BRD9 with a higher affinity (Kd=14 nM, ITC) than to BRD7 (Kd=239nM, ITC), is completely negative on BET family members (>100 µM by AlphaScreen) and demonstrates cellular activity by FRAP on BRD9 and BRD7 at 0.1 µM and 1 µM, respectively. BI-9564 shows off-target selectivity to CECR2 in vitro (258 nM, ITC), but not in cells (at 1 µM, FRAP).
