CDDO(Bardoxolone; RTA 401) 产品说明书 Chemicals
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产品编号 DC8361
名称 CDDO(Bardoxolone; RTA 401)

化学性质

CAS 218600-44-3
分子式 C31H41NO4
分子量 491.66
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM.By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis.In various cancer cell lines, CDDO has been shown to specifically inhibit proliferation and induce apoptosis.Mechanism studies revealed that CDDO is a ligand for peroxisome proliferator-activated receptor γ, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity. For the detailed information of CDDO(Bardoxolone; RTA 401), the solubility of CDDO(Bardoxolone; RTA 401) in water, the solubility of CDDO(Bardoxolone; RTA 401) in DMSO, the solubility of CDDO(Bardoxolone; RTA 401) in PBS buffer, the animal experiment (test) of CDDO(Bardoxolone; RTA 401), the cell expriment (test) of CDDO(Bardoxolone; RTA 401), the in vivo, in vitro and clinical trial test of CDDO(Bardoxolone; RTA 401), the EC50, IC50,and affinity,of CDDO(Bardoxolone; RTA 401), For the detailed information of CDDO(Bardoxolone; RTA 401), the solubility of CDDO(Bardoxolone; RTA 401) in water, the solubility of CDDO(Bardoxolone; RTA 401) in DMSO, the solubility of CDDO(Bardoxolone; RTA 401) in PBS buffer, the animal experiment (test) of CDDO(Bardoxolone; RTA 401), the cell expriment (test) of CDDO(Bardoxolone; RTA 401), the in vivo, in vitro and clinical trial test of CDDO(Bardoxolone; RTA 401), the EC50, IC50,and affinity,of CDDO(Bardoxolone; RTA 401), Please contact DC Chemicals.
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