JI051 产品说明书 Chemicals
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产品编号 DC22122
名称 JI051

化学性质

CAS 2234281-75-3
分子式 C22H24N2O3
分子量 364.445
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


JI051(JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression; inhibits HEK293 cell proliferation with EC50 of 0.3 uM, interacts with prohibitin 2 (PHB2), stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest; dose-dependently reduces cell growth of the human pancreatic cancer cell line MIA PaCa-2.
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