AMG-510 产品说明书 Chemicals
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产品编号 DC22298
名称 AMG-510

化学性质

CAS 2296729-00-3
分子式 C30H30F2N6O3
分子量 560.594413280487
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description AMG-510 is a specific covalent inhibitor of K-RAS(G12C) with potential antineoplastic activity.
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


AMG-510 is a specific covalent inhibitor of K-RAS(G12C) with potential antineoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, thro
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