PBIT 产品说明书 Chemicals
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产品编号 DC7550
名称 PBIT

化学性质

CAS 2514-30-9
分子式 C14H11NOS
分子量 241.31
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro. PBIT treatment inhibits removal of H3K4me3 by JARID1B in cells and inhibits proliferatio
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