Mad2 inhibitor-1 (M2I-1) 产品说明书 Chemicals
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产品编号 DC9741
名称 Mad2 inhibitor-1 (M2I-1)

化学性质

CAS 312271-03-7
分子式 C19H24N4O4S
分子量 404.48
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


Mad2 inhibitor-1 (M2I-1) is the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the SAC. M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. Cellular studies revealed that M2I-1 weakens the SAC response, indicating that the compound might be active in cells.
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