2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity; prevents the adhesion of α4 integrin-expressing cells, antagonizes VCAM-1-mediated degranulation of mast cells and eosinophils and ERK 1/2 phosphorylation; does not inhibit cell adhesion mediated by the leukocyte integrins aLb2 and aMb2 or by the Arg-GlyAsp (RGD)-binding integrins α5β1, αVβ3, αVβ5, αVβ6 and αIIbβ3; dose-dependently reduces the clinical symptoms of allergic conjunctivitis, conjunctival α4 integrin expression and conjunctival levels of chemokines and cytokines in ovalbumin-sensitized guinea pigs.
