2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
IQ-1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on.
1、IQ-1 maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner.
2、IQ-1 decreased Wnt-stimulated phosphorylation of p300 at Ser-89.
3、 IQ-1 binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.
4、The binding of IQ-1 to PR72/130 leads to decreased phosphorylation of the coactivator protein p300 at Ser-89.
5、IQ-1 thereby diminishes the β-catenin/p300 interaction and prevents β-catenin coactivator switching from CBP to p300.
