2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. Sirtinol has been shown to inhibit yeast Sir2 (IC50 = 70 μM), human SIRT2 (IC50 = 40 μM), and human SIRT1 (IC50 = 131 μM), yet has shown no effect on human HDAC1. In Arabidopsis, sirtinol strongly affected root and vascular tissue development by activating the auxin signaling pathway. Sirtinol has also been shown to induce senescence-like growth arrest in human breast cancer MCF-7 and lung cancer H1299 cells by impaired activation of MAPK.
