2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
GGTI 2418 (PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase; demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4 nM; suppresses the growth of human breast tumors in nude mouse xenografts; increases p27(Kip1) and induces significant regression of breast tumors.
