2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
SU 4312 is a selective, cell-permeable inhibitor of VEGFR2 and PDGFR tyrosine kinases (IC50s = 0.8 and 19.4 μM, respectively).It demonstrates IC50 values >100 μM at EGFR, HER2, and IGF-1R.SU 4312 has been shown to inhibit VEGF-dependent angiogenesis in a zebrafish assay (IC50 = 1.8 µM) without affecting normal cells.SU 4312 has also been shown to prevent MPP+-induced neuronal apoptosis in vitro, as well as to decrease MPTP-induced loss of dopaminergic neurons, reduce expression of mRNA for tyrosine hydroxylase, and impair swimming behavior in zebrafish.
