2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
ATN-224 (Choline tetrathiomolybdate;WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM against purified bovine SOD1, leading to antiangiogenic and antitumour effects; shows no binding to calcium, iron, magnesium, zinc, or manganese ions at 1 mM; inhibits HUVEC proliferation with IC50 1.4 uM; shows a potential therapy against Wilson's disease.Other IndicationPhase 3 Clinical
