Kevetrin HCl 产品说明书 Chemicals
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产品编号 DC8326
名称 Kevetrin HCl

化学性质

CAS 66592-89-0
分子式 C5H10CLN3S
分子量 179.67
存储条件 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

生物活性

Description
In Vivo
In Vitro

化合物的使用

Kinase Assay
Cell Assay
Animal Administration

参考文献


Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. For the detailed information of Kevetrin HCl, the solubility of Kevetrin HCl in water, the solubility of Kevetrin HCl in DMSO, the solubility of Kevetrin HCl in PBS buffer, the animal experiment (test) of Kevetrin HCl, the cell expriment (test) of Kevetrin HCl, the in vivo, in vitro and clinical trial test of Kevetrin HCl, the EC50, IC50,and affinity,of Kevetrin HCl, For the detailed information of Kevetrin HCl, the solubility of Kevetrin HCl in water, the solubility of Kevetrin HCl in DMSO, the solubility of Kevetrin HCl in PBS buffer, the animal experiment (test) of Kevetrin HCl, the cell expriment (test) of Kevetrin HCl, the in vivo, in vitro and clinical trial test of Kevetrin HCl, the EC50, IC50,and affinity,of Kevetrin HCl, Please contact DC Chemicals.
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