2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
BMS-707035 is a pyrimidine carboxamide similar to Raltegravir. BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity. BMS-707035 binding and target DNA binding to IN are mutually exclusive events, as elucidated by the fact that increasing the amount of target DNA overcomes the inhibition of strand transfer catalysis by BMS-707035. BMS-707035 binding affinity to IN is also affected by the four terminal bases at the 5’ end of the pre-processed U5 long terminal repeat (LTR).
