2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
E-64c is a synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor isolated from Aspergillus japonicus.E-64c inhibits the cysteine proteases cathepsin B and cathepsin L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.The ethyl ester of E-64c, E-64d, is cell permeable and hydrolyzed in cell culture to E-64c. E-64d arrests the growth of A431 cells in metaphase at concentrations between 20-200 µg/ml.
