2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
TPI-1 is a potent and
selective SHP-1 inhibitor effective at low nanomolar levels. TPI-1 inhibited recombinant SHP-1 with IC50 at ∼10 ng/ml
(and increased SHP-1 phospho-substrates pLck-pY394,
pZap70, and pSlp76 in Jurkat T cells starting at 10 ng/ml.
Its selectivity was indicated by its reduced effectiveness foTPI-1 increases IFN-g+ cells in mouse splenocytes and human
peripheral blood in vitro.TPI-1 increases mouse spleen pLck-pY394 and IFN-g+ cells
in vivo.TPI-1 inhibits the growth of B16 melanoma tumors in mice as
a tolerated single agent
