2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
生物活性
Description
In Vivo
In Vitro
化合物的使用
Kinase Assay
Cell Assay
Animal Administration
参考文献
WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 µM.1 It also induces apoptosis in U87-MG (IC50 = 5.6 µM) and U373-MG (IC50 = 3.7 µM) cells.WP1066 is orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity, including immune activation as indicated by the up-regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats. For the detailed information of wp1066（STAT Inhibitor III）, the solubility of wp1066（STAT Inhibitor III） in water, the solubility of wp1066（STAT Inhibitor III） in DMSO, the solubility of wp1066（STAT Inhibitor III） in PBS buffer, the animal experiment (test) of wp1066（STAT Inhibitor III）, the cell expriment (test) of wp1066（STAT Inhibitor III）, the in vivo, in vitro and clinical trial test of wp1066（STAT Inhibitor III）, the EC50, IC50,and affinity,of wp1066（STAT Inhibitor III）, For the detailed information of wp1066（STAT Inhibitor III）, the solubility of wp1066（STAT Inhibitor III） in water, the solubility of wp1066（STAT Inhibitor III） in DMSO, the solubility of wp1066（STAT Inhibitor III） in PBS buffer, the animal experiment (test) of wp1066（STAT Inhibitor III）, the cell expriment (test) of wp1066（STAT Inhibitor III）, the in vivo, in vitro and clinical trial test of wp1066（STAT Inhibitor III）, the EC50, IC50,and affinity,of wp1066（STAT Inhibitor III）, Please contact DC Chemicals.
